Rabbit Anti-CD137 antibody | Sunlong Medical

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Tumor necrosis factor receptor superfamily member 9; TNFRSF9; 4-1BB; 4 1BB; 4 1BB ligand receptor; Homolog of mouse 4 1BB; Receptor protein 4 1BB; T cell antigen 4 1BB homolog; T cell antigen ILA; CDw137; CD 137; CD137 antigen; Induced by lymphocyte activ

Cat:

SL2449R

Species Reactivity：

Human,Mouse,

Immunogen：

KLH conjugated synthetic peptide derived from human CD137:101-200/255

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: HepG2(Human) Cell Lysate at 30 ugPrimary: Anti-CD137 (SL2449R) at 1/500 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 25 kDObserved band size: 39 kDSample: Lane 1: Mouse Thymus Lysates Lane 2: Mouse Spleen Lysates Lane 2: Mouse Lymph Lysates Primary: Anti-CD137 (SL2449R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 25kDaObserved band size: 42kDa

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Unit:

Price: $220.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival.

Function:
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Subunit:
Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed on the surface of activated T-cells.

Similarity:
Contains 4 TNFR-Cys repeats.

SWISS:
Q07011

Gene ID:
724

Database links:

Entrez Gene: 724 Human

Omim: 602250 Human

SwissProt: Q07011 Human

Unigene: 654459 Human

CD137属于肿瘤坏死因子超家族成员，是可诱导的T细胞共刺激受体，表达于CD4 + 和CD8 + T细胞、活化的自然杀伤细胞（natural killercell，NK）和树突状细胞,CD137可抑制T细胞增殖，诱发细胞凋亡。 Picture

Sample:
Lane 1: Mouse Thymus Lysates
Lane 2: Mouse Spleen Lysates
Lane 2: Mouse Lymph Lysates
Primary: Anti-CD137 (SL2449R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 25kDa
Observed band size: 42kDa

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