HSD11B1 is a microsomal enzyme that catalyses the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyse the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
Subunit:
Homodimer.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Tissue Specificity:
Widely expressed. Highest expression in liver.
Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SWISS:
P28845
Gene ID:
3290
Database links:
Entrez Gene: 3290 Human
Entrez Gene: 15483 Mouse
Entrez Gene: 25116 Rat
Omim: 600713 Human
SwissProt: Q6R0J2 Hamster
SwissProt: P28845 Human
SwissProt: P50172 Mouse
SwissProt: Q7M3I4 Rabbit
SwissProt: P16232 Rat
Unigene: 195040 Human
Unigene: 28328 Mouse
Unigene: 185798 Rat
Unigene: 888 Rat
| Picture |
This image was kindly submitted by Dragos Scarlet DVM, MSc from the University of Vienna as part of the Bioss Discovery Progarm. Paraffin embedded horse kidney labeled with Anti-HSD11B1 Polyclonal Antibody, Unconjugated (SL3904R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
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