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Home > Product > Antibody > Rabbit Anti-Hexokinase 2 antibody
Hexokinase II; Hexokinase 2 muscle; Hexokinase type II; Hexokinase-2; HK 2; HK II; HK2; HKII; HxK 2; HxK2; HXK2_HUMAN; Muscle form hexokinase; DKFZp686M1669.
Cat:
SL3993R
Species Reactivity：
Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Horse,Rabbit,)
Immunogen：
KLH conjugated synthetic peptide derived from human Hexokinase 2:101-200/917
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: Skeletal muscle (Mouse) Lysate at 40 ugPrimary: Anti-Hexokinase 2 (SL3993R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 101 kDObserved band size: 101 kD
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Price: $
Product PDFs
Datasheet:


The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose-6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases. HXK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines. HXK II is involved in the uptake and utilization of glucose by adipose and skeletal tissues. Of the hexokinases, HXK III has the highest affinity for glucose. Glucokinase is expressed in pancreatic beta cells where it functions as a glucose sensor, determining the “set point” for insulin secretion.

Function:
Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.

Subunit:
Monomer.

Subcellular Location:
Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.

Tissue Specificity:
Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.

Similarity:
Belongs to the hexokinase family.

SWISS:
P52789

Gene ID:
3099

Database links:

Entrez Gene: 3099 Human

Entrez Gene: 15277 Mouse

Entrez Gene: 25059 Rat

Omim: 601125 Human

SwissProt: P52789 Human

SwissProt: O08528 Mouse

SwissProt: P27881 Rat

Unigene: 406266 Human

Unigene: 591588 Human

Unigene: 255848 Mouse

Unigene: 469167 Mouse

Unigene: 91375 Rat



Picture

Sample:
Skeletal muscle (Mouse) Lysate at 40 ug
Primary: Anti-Hexokinase 2 (SL3993R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 101 kD
Observed band size: 101 kD
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