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Home > Product > Antibody > Rabbit Anti-ELAC2/HPC2 antibody
elaC homolog 2; ElaC homolog protein 2; ELC2; Heredity prostate cancer protein 2; HPC2; putative prostate cancer susceptibility protein HPC2/ELAC2; Ribonuclease Z2; RNase Z2; tRNA 3 endonuclease 2; tRNase Z (long form); tRNase Z2; Zinc phosphodiesterase E
Cat:
SL4276R
Species Reactivity：
Human,(predicted: Mouse,Rat,Dog,Rabbit,)
Immunogen：
KLH conjugated synthetic peptide derived from human ELAC2:88-190/826
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ELAC2) Polyclonal Antibody, Unconjugated (SL4276R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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Product PDFs
Datasheet:


ELAC2 is a zinc phosphodiesterase which displays some tRNA 3' processing endonuclease activity. It is thought to be involved in tRNA maturation, acting by removing a 3' trailer from precursor tRNA. ELAC2 also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. A number of allelic variants have been investigated in hereditary prostate cancer.

Function:
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

Subunit:
Homodimer. Interacts with PTCD1.

Subcellular Location:
Mitochondrion. Nucleus. Note=Mainly mitochondrial.

Tissue Specificity:
Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.

Similarity:
Belongs to the RNase Z family.

SWISS:
Q9BQ52

Gene ID:
60528

Database links:

Entrez Gene: 60528 Human

Entrez Gene: 68626 Mouse

Entrez Gene: 282826 Rat

Omim: 605367 Human

SwissProt: Q9BQ52 Human

SwissProt: Q80Y81 Mouse

SwissProt: Q8CGS5 Rat

Unigene: 434232 Human

Unigene: 157711 Mouse

Unigene: 163124 Rat



Picture

Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ELAC2) Polyclonal Antibody, Unconjugated (SL4276R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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