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Home > Product > Antibody > Rabbit Anti-TACC2 antibody
TACC2_HUMAN; Anti zuai 1; AZU 1; AZU1; ECTACC; TACC 2; Transforming acidic coiled coil containing protein 2.
Cat:
SL5736R
Species Reactivity：
Human,(predicted: Mouse,Rat,Dog,Cow,Rabbit,)
Immunogen：
KLH conjugated synthetic peptide derived from human TACC2:2851-2948/2948
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TACC2) Polyclonal Antibody, Unconjugated (SL5736R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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Product PDFs
Datasheet:


TACC2 is a conserved family of centrosome and microtubule interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.

Function:
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.

Subunit:
Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome.

Tissue Specificity:
Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea.

Post-translational modifications:
Phosphorylated by TTK; which is required for localization in centrosome.

Similarity:
Belongs to the TACC family.
Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain.

SWISS:
O95359

Gene ID:
10579

Database links:

Entrez Gene: 10579 Human

Entrez Gene: 57752 Mouse

Entrez Gene: 309025 Rat

Omim: 605302 Human

SwissProt: O95359 Human

SwissProt: Q811U0 Mouse

Unigene: 501252 Human

Unigene: 86322 Mouse

Unigene: 13989 Rat



Picture

Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TACC2) Polyclonal Antibody, Unconjugated (SL5736R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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