The BMP15 protein is a member of the bone morphogenetic protein family which is part of the transforming growth factor beta superfamily. The transforming growth factor beta superfamily includes large families of growth and differentiation factors. It is thought that BMP15 may be involved in oocyte maturation and follicular development as a homodimer, or by forming heterodimers with a related protein, Gdf9.
Function: May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Subunit: Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked.
Subcellular Location: Secreted.
DISEASE: Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2) [MIM:300510]; also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4) [MIM:300510]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Sample:
A549(Human) Cell Lysate at 40 ug
Primary: Anti-BMP15 (SL6612R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 14 kD
Observed band size: 14 kD
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Specific References (1) | SL6612R has been referenced in 1 publications.
[IF=1.281] Pinar Kacamak. et al. The Effect of Isotretinoin on Oocyte Maturation in Adolescent Female Rats. Gynecol Obstet Inves. 2020;85(4):327-335 IHC ; Rat.
