Inhibits glucokinase by forming an inactive complex with this enzyme.
Tissue Specificity:
Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.
Similarity:
Belongs to the GCKR family.
Contains 2 SIS domains.
SWISS:
Q14397
Gene ID:
2646
Database links:
Entrez Gene: 2646 Human
Entrez Gene: 231103 Mouse
Omim: 600842 Human
SwissProt: Q14397 Human
SwissProt: Q91X44 Mouse
Unigene: 89771 Human
Unigene: 100043 Mouse
Picture |
Tissue/cell: rat liver tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-GCKR/Glucokinase regulatory protein Polyclonal Antibody, Unconjugated (SL7057R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining
|
|
|