This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Subunit:
Associated with sarcolipin (SLN) and phospholamban (PLN) (By similarity).
Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity:
Skeletal muscle, fast twitch muscle (type II) fibers.
DISEASE:
Defects in ATP2A1 are the cause of Brody myopathy (BRM) [MIM:601003]. An autosomal recessive myopathy characterized by increasing impairment of relaxation of fast twist skeletal muscle during exercise.
Similarity:
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
SWISS:
O14983
Gene ID:
487
Database links:
Entrez Gene: 518117 Cow
Entrez Gene: 487 Human
Entrez Gene: 11937 Mouse
Entrez Gene: 100037716 Rabbit
Entrez Gene: 116601 Rat
Omim: 108730 Human
SwissProt: Q0VCY0 Cow
SwissProt: O14983 Human
SwissProt: Q8R429 Mouse
SwissProt: P04191 Rabbit
SwissProt: Q64578 Rat
Unigene: 657344 Human
Unigene: 35134 Mouse
Unigene: 217139 Rat
| Picture |
Paraformaldehyde-fixed, paraffin embedded (rat heart tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AT2A1) Polyclonal Antibody, Unconjugated (SL7539R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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