Rabbit Anti-RING finger protein 189 antibody

Home > Product > Antibody > Rabbit Anti-RING finger protein 189 antibody

CARP-2; CARP2; Caspase regulator CARP2; Caspases 8 and 10 associated RING finger protein 2; Caspases-8 and -10-associated RING finger protein 2; E3 ubiquitin protein ligase rififylin; E3 ubiquitin-protein ligase rififylin; Fring; FYVE RING finger protein

Cat:

SL6872R

Species Reactivity：

Human,(predicted: Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human RING finger protein 189:251-363/363

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Sample: Liver (Mouse) Lysate at 40 ugPrimary: Anti-RING finger protein 189 (SL6872R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 40 kDObserved band size: 40 kD

prev next

Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.

Subunit:
Binds CASP8 and CASP10.

Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein.

Tissue Specificity:
Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Post-translational modifications:
Rapidly degraded after stimulation with TNFSF10, probably by caspases.
Auto-ubiquitinated (in vitro).
Palmitoylated.

Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 RING-type zinc finger.
Contains 2 SAP domains.

SWISS:
Q8WZ73

Gene ID:
117584

Database links:

Entrez Gene: 530263 Cow

Entrez Gene: 117584 Human

Entrez Gene: 67338 Mouse

Entrez Gene: 282844 Rat

Omim: 609735 Human

SwissProt: Q8WZ73 Human

SwissProt: Q6ZQM0 Mouse

SwissProt: Q8CIN9 Rat

Unigene: 1736 Human

Unigene: 341608 Mouse

Unigene: 159718 Rat

Picture

Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti-RING finger protein 189 (SL6872R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 40 kD
Observed band size: 40 kD

Product Feedback Wall