Rabbit Anti-BS69 antibody | Sunlong Medical

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Adenovirus 5 E1A binding protein; Bone morphogenetic protein receptor associated molecule 1; BRAM1; BS69 variant 1; BS69 variant 2; BS69 variant 3; BS69 variant 4; Zinc finger MYND domain containing 11; ZMYND11.

Cat:

SL7697R

Species Reactivity：

Rat,(predicted: Human,Mouse,Chicken,Dog,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human ZMYND11/BS69:501-602/602

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min; Incubation: Anti-BS69/Adenovirus 5 E1A binding protein Polyclonal Antibody, Unconjugated (SL7697R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Function:
Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors.

Subunit:
Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif). Interacts (via MYND-type zinc finger) with EZH2. Interacts with E2F6.

Subcellular Location:
Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Ubiquitinated, leading to proteasomal degradation.

Similarity:
Contains 1 bromo domain.
Contains 1 MYND-type zinc finger.
Contains 1 PHD-type zinc finger.
Contains 1 PWWP domain.

SWISS:
Q15326

Gene ID:
10771

Database links:

Entrez Gene: 10771 Human

Entrez Gene: 66505 Mouse

Entrez Gene: 291259 Rat

GenBank: NP_006615 Human

GenBank: NP_997644 Human

Omim: 608668 Human

SwissProt: Q15326 Human

SwissProt: Q8R5C8 Mouse

Unigene: 292265 Human

Unigene: 397307 Mouse

Unigene: 38301 Rat

Picture

Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-BS69/Adenovirus 5 E1A binding protein Polyclonal Antibody, Unconjugated (SL7697R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

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