Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008].
Function:
Has hepatocyte mitogenic activity.
Subunit:
Homodimer (Probable).
Subcellular Location:
Secreted.
Tissue Specificity:
Liver specific.
Similarity:
Contains 1 fibrinogen SLCterminal domain.
SWISS:
Q08830
Gene ID:
2267
Database links:
Entrez Gene: 508090 Cow
Entrez Gene: 2267 Human
Entrez Gene: 234199 Mouse
Entrez Gene: 246186 Rat
Omim: 605776 Human
SwissProt: Q3SZZ7 Cow
SwissProt: Q08830 Human
SwissProt: Q71KU9 Mouse
SwissProt: Q5M8C6 Rat
Unigene: 491143 Human
Unigene: 277955 Mouse
Unigene: 15994 Rat
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Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti- HFREP1 (SL6894R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 32 kD
Observed band size: 35 kD
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