Rabbit Anti-CDC123 antibody

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C10orf7; CD123_HUMAN; CDC123; Cell division cycle protein 123 homolog; D123; HT 1080; HT-1080; Protein D123; PZ32.

Cat:

SL7781R

Species Reactivity：

Human,(predicted: Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CDC123/C10orf7:101-200/336

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000Flow-Cyt=1μg/Testnot yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Blank control: U937(fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-CDC123 antibody(SL7781R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG (orange) ,used under the same conditions. Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Required for S phase entry of the cell cycle.The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.

Function:
Required for S phase entry of the cell cycle

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.

Similarity:
Belongs to the CDC123 family.

SWISS:
O75794

Gene ID:
8872

Database links:

Entrez Gene: 8872 Human

Entrez Gene: 98828 Mouse

Entrez Gene: 116656 Rat

SwissProt: O75794 Human

SwissProt: Q8CII2 Mouse

SwissProt: Q62834 Rat

Unigene: 412842 Human

Unigene: 181490 Mouse

Unigene: 11096 Rat

Picture

Blank control: U937(fixed with 2% paraformaldehyde (10 min)).
Primary Antibody: Rabbit Anti-CDC123 antibody(SL7781R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG (orange) ,used under the same conditions.
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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