FAM153A, FAM153B and FAM153C are 310, 387 and 144 amino acid proteins, respectively, that are encoded by a genes mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Similarity:
Belongs to the FAM153 family.
SWISS:
P0C7A2
Gene ID:
202134
Database links:
Entrez Gene: 202134 Human
SwissProt: P0C7A2 Human
Unigene: 368516 Human
Unigene: 646912 Human
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Sample: A549 Cell (Human) Lysate at 40 ug
Primary: Anti-FAM153B (SL8221R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 44 kD
Observed band size: 40 kD
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