Rabbit Anti-UQCRC1 antibody

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Ubiquinol-Cytochrome C Reductase Core Protein I; mitochondrial; Complex III subunit 1; Core protein I; Cytochrome b c1 complex subunit 1, mitochondrial; Cytochrome b-c1 complex subunit 1; D3S3191; OTTHUMP00000164820; QCR1; QCR1_HUMAN; Ubiquinol cytochrome

Cat:

SL8298R

Species Reactivity：

Human,(predicted: Mouse,Rat,Cow,Monkey,y)

Immunogen：

KLH conjugated synthetic peptide derived from human UQCRC1:65-170/480

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min; Incubation: Anti-UQCRC1 Polyclonal Antibody, Unconjugated(SL8298R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

Subunit:
The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Subcellular Location:
Mitochondrion inner membrane.

Post-translational modifications:
Acetylation of Lys-138 is observed in liver mitochondria from fasted mice but not from fed mice.

Similarity:
Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.

SWISS:
P31930

Gene ID:
54878

Database links:

Entrez Gene: 54878 Human

Entrez Gene: 74388 Mouse

Entrez Gene: 315758 Rat

Omim: 606819 Human

SwissProt: Q6V1X1 Human

SwissProt: Q80YA7 Mouse

Unigene: 591106 Human

Unigene: 202749 Mouse

Unigene: 391842 Mouse

Picture

Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-UQCRC1 Polyclonal Antibody, Unconjugated(SL8298R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining

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