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Home > Product > Antibody > Rabbit Anti-BTBD3 antibody
BTB (POZ) domain containing 3; BTB domain containing 3; BTB/POZ domain containing protein 3; BTB/POZ domain-containing protein 3; BTBD3 protein; BTBD3_HUMAN.
Cat:
SL8397R
Species Reactivity：
Rat,(predicted: Human,Mouse,Chicken,Dog,Pig,Cow,Horse,)
Immunogen：
KLH conjugated synthetic peptide derived from human BTBD3:417-522/522
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:50-200（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (BTBD3) Polyclonal Antibody, Unconjugated (SL8397R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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Product PDFs
Datasheet:


BTBD3 is a 522 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD3 may play a role in transcription regulation.

Similarity:
Contains 1 BTB (POZ) domain.

SWISS:
Q9Y2F9

Gene ID:
22903

Database links:

Entrez Gene: 22903 Human

Entrez Gene: 228662 Mouse

Entrez Gene: 311462 Rat

Omim: 615566 Human

SwissProt: Q9Y2F9 Human

SwissProt: P58545 Mouse

Unigene: 709366 Human

Unigene: 153405 Mouse

Unigene: 224562 Rat



Picture

Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (BTBD3) Polyclonal Antibody, Unconjugated (SL8397R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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