E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
Subunit:
Interacts with UBE2L3, UBE2L6 and UCKL1.
Subcellular Location:
Cytoplasmic granule membrane.
Tissue Specificity:
Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells. Present in natural killer cells
Similarity:
Belongs to the RBR family. RNF19 subfamily.
Contains 1 IBR-type zinc finger.
Contains 2 RING-type zinc fingers.
SWISS:
Q6ZMZ0
Gene ID:
127544
Database links:
Entrez Gene: 127544 Human
Omim: 610872 Human
SwissProt: Q6ZMZ0 Human
Unigene: 591504 Human
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Paraformaldehyde-fixed, paraffin embedded (Human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RNF19B) Polyclonal Antibody, Unconjugated (SL9246R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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