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PRDM1_HUMAN; PR domain zinc finger protein 1; BLIMP1; EC:2.1.1.- ; BLIMP-1; BLIMP1; Beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1; Positive regulatory domain I-binding factor 1 (PRDI-BF1; PRDI-binding fac
Cat:
SL6466R
Species Reactivity：
Mouse,(predicted: Human,Rat,Chicken,Pig,Cow,Horse,Rabbit,)
Immunogen：
KLH conjugated synthetic peptide derived from human PRDM1:501-600/825
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500IF=1:50-200（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (mouse lymphoid tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PRDM1) Polyclonal Antibody, Unconjugated (SL6466R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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Product PDFs
Datasheet:


This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

Function:
Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.

Subunit:
Interacts with PRMT5.

Subcellular Location:
Nucleus. Cytoplasm.

Similarity:
Contains 4 C2H2-type zinc fingers.
Contains 1 SET domain.

SWISS:
O75626

Gene ID:
639

Database links:

Entrez Gene: 538384 Cow

Entrez Gene: 481947 Dog

Entrez Gene: 639 Human

Entrez Gene: 12142 Mouse

Entrez Gene: 309871 Rat

SwissProt: O75626 Human

SwissProt: Q60636 Mouse



Picture

Paraformaldehyde-fixed, paraffin embedded (mouse lymphoid tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PRDM1) Polyclonal Antibody, Unconjugated (SL6466R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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