E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.
Function:
E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity).
Subunit:
Interacts (YXXL motif) with AP1M1. Interacts (via PDZ-binding motif) with LIN7A. Interacts with unidentified fucose glycoproteins (By similarity).
Subcellular Location:
Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity).
Similarity:
Contains 1 RING-CH-type zinc finger.
SWISS:
A6NNE9
Gene ID:
441061
Database links:
Entrez Gene: 441061 Human
Omim: 613338 Human
SwissProt: A6NNE9 Human
Unigene: 662216 Human
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Sample:
Siha(Human) Cell Lysate at 30 ug
Primary: Anti- MARCH11 (SL9345R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 44 kD
Observed band size: 44 kD
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