HGF activator belongs to the peptidase family S1 and activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form. HGF Activator is produced as a zymogen, and the form found in serum is largely the inactive single-chain form. It is activated to a heterodimeric form by endoproteolytic processing.
Function: Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.
Subunit: Heterodimer of a short chain and a long chain linked by a disulfide bond.
Subcellular Location: Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
