FAM84A is a 292 amino acid protein that belongs to the FAM84 family of proteins. Predominantly expressed in testis, FAM84A shares 44% amino acid identity with the related protein FAM84B. FAM84A localizes to a subcellular membrane region where there is no contact between neighboring cells and is believed to play a role in cell morphology and motility. More specifically, the expression of FAM84A increases cell motility. Two FAM84A isoforms are expressed due to alternative splicing events. Isoform 2 can be phosphorylated on various serine residues and this phosphorylation is associated with cellular morphology. FAM84A is upregulated in colorectal cancer, lung cancer, pancreatic cancer, cholangiocarcinoma and bladder cancer tissues. Via its ability to increase cell motility, FAM84A may contribute to the invasion and metastasis of cancer cells.
Post-translational modifications:
Isoform 2 is phosphorylated.
Similarity:
Belongs to the FAM84 family.
SWISS:
Q96KN4
Gene ID:
151354
Database links:
Entrez Gene: 151354 Human
Entrez Gene: 105005 Mouse
Entrez Gene: 313969 Rat
Omim: 611234 Human
SwissProt: Q96KN4 Human
SwissProt: Q9D650 Mouse
SwissProt: B2RYB4 Rat
Unigene: 260855 Human
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Paraformaldehyde-fixed, paraffin embedded (rat rectum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FAM84A) Polyclonal Antibody, Unconjugated (SL11010) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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