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Home > Product > Antibody > Rabbit Anti-HGFA Inhibitor 2 antibody
Bikunin, placental; DIAR3; HAI-2; HAI2; Hepatocyte growth factor activator inhibitor type 2; Kop; Kunitz type protease inhibitor 2; Kunitz-type protease inhibitor 2; Kunitz-type serine protease inhibitor; PB; Placental bikunin; HGFA Inhibitor2; HGFA Inhib
Cat:
SL10062R
Species Reactivity：
Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Horse,Guinea Pig,)
Immunogen：
KLH conjugated synthetic peptide derived from human SPINT2:31-130/252<Extracellular>
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1μg/TestICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Blank control(blue): Mouse thymus cells(fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti- HGFA antibody(SL10062R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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Unit:
Price: $
Product PDFs
Datasheet:


Tissue damage, such as hepatic and renal injury, initiates hepatocyte growth factor activator (HGFAC)-mediated limited proteolytic activation of the inactive single-chain precursor form of HGF. Initially, HGFAC is produced as a precursor protein, which is activated by limited proteolysis and is neutralized by specific inhibitors known as HGF activator inhibitors, designated HAIs. HAIs belong to the Kunitz-type serine protease inhibitor family. HAIs target HGF activator and are involved in the regulation of proteolytic activation of HGF in injured tissues. Human HAI-1 transcript is expressed in various human tissues, such as adult placenta, kidney, pancreas, prostate and small intestine, and fetal kidney and lung. It translates into a 478 amino acid protein. The human HAI-2 gene maps to chromosome 19q13.1 and encodes a 252 amino acid protein, also designated human placental bikunin or kop (Kunitz domain containing protein over-expressed in pancreatic cancer). HAI-1 and HAI-2 are produced in membrane-associated forms, which are secreted as active, proteolytically truncated proteins.

Function:
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.

DISEASE:
Defects in SPINT2 are the cause of diarrhea type 3 (DIAR3) [MIM:270420]; also known as congenital sodium diarrhea (CSD). DIAR3 is a rare, inherited diarrhea of infancy. A diagnosis of DIAR3 is made on the findings of a life-threatening secretory diarrhea, severe metabolic acidosis, and hyponatremia secondary to extraordinarily high fecal losses of sodium, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune, and endocrine causes.

Similarity:
Contains 2 BPTI/Kunitz inhibitor domains.

SWISS:
O43291

Gene ID:
10653

Database links:

Entrez Gene: 10653 Human

Entrez Gene: 20733 Mouse

Entrez Gene: 292770 Rat

Omim: 605124 Human

SwissProt: O43291 Human

SwissProt: Q9WU03 Mouse

Unigene: 31439 Human

Unigene: 295230 Mouse



Picture

Blank control(blue): Mouse thymus cells(fixed with 2% paraformaldehyde (10 min)).
Primary Antibody:Rabbit Anti- HGFA antibody(SL10062R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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