C1QL3 (Complement C1q Like 3) is a Protein Coding gene. An important paralog of this gene is C1QL1.
Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).
Subunit:
Interacts with BAI3 (By similarity).
Subcellular Location:
Secreted (Potential).
Similarity:
Contains 1 C1q domain.
Contains 1 collagen-like domain.
SWISS:
Q5VWW1
Gene ID:
389941
Database links:
Entrez Gene: 389941 Human
Entrez Gene: 227580 Mouse
SwissProt: Q5VWW1 Human
SwissProt: Q9ESN4 Mouse
Unigene: 676792 Human
Unigene: 727706 Human
Unigene: 229322 Mouse
Unigene: 477072 Mouse
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Paraformaldehyde-fixed, paraffin embedded (rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (C1QL3) Polyclonal Antibody, Unconjugated (SL15083R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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