MUC13 Down regulated in colon cancer 1; DRCC1; MUC 13; MUC-13; Mucin 13, cell surface associated; RECC; UNQ6194; MUC13_HUMAN.
Cat:
SL10074R
Species Reactivity：
Mouse,(predicted: Human,Rat,Pig,Horse,)
Immunogen：
KLH conjugated synthetic peptide derived from human MUC13:175-270/511<Extracellular>
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample:Kidney (Mouse)Lysate at 40 ugPrimary: Anti- MUC13(SL10074R)at 1/300 dilutionSecondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilutionPredicted band size: 54kDObserved band size: 54kD
MUC13 is a mucin. These are secreted or transmembrane glycoproteins that are expressed mainly in the digestive tract and on epithelial surfaces. MUC13 is upregulated in gastric cancer. Mucins have also been implicated in inflammatory bowel diseases.
Function: Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.
Subunit: Homodimer of beta subunits.
Subcellular Location: Cell membrane; Single-pass type I membrane protein (Potential). Secreted. Note=Also exists as a soluble form.
Tissue Specificity: Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.
Post-translational modifications: Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homo-oligomerization into dimers is dependent on intrachain disulfide bonds.
Highly N-glycosylated.
Sample:Kidney (Mouse)Lysate at 40 ug
Primary: Anti- MUC13(SL10074R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 54kD
Observed band size: 54kD
