Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
Function:
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
Subcellular Location:
Golgi apparatus membrane.
Tissue Specificity:
Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.
Post-translational modifications:
Fucosylation is essential for binding to E-selectin.
N-glycosylated. Contains sialic acid residues.
DISEASE:
Expressed both in adult and fetal tissues.
Similarity:
Contains 16 Cys-rich GLG1 repeats.
SWISS:
Q92896
Gene ID:
2734
Database links:
Entrez Gene: 396492 Chicken
Entrez Gene: 2734 Human
Entrez Gene: 20340 Mouse
Omim: 600753 Human
SwissProt: Q02391 Chicken
SwissProt: Q92896 Human
SwissProt: Q61543 Mouse
Unigene: 109731 Human
Unigene: 276271 Mouse
Unigene: 88619 Mouse
| Picture |
Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Golgi Complex) Polyclonal Antibody, Unconjugated (SL13485R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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