The two G protein-coupled receptors GPR7 and GPR8 display high similarity to each other. They both show high expression in brain and in particular in hypothalamus, and have been characterized as receptors for neuropeptide W (NPW) and neuropeptide B (NPB). In response to NPW and NPB, they play a role in the regulation of feeding behavior. GPR7 deficient mice develop an adult-onset obese phenotype that progressively worsens with age and is exacerbated when fed a high-fat diet. The genes encoding human GPR7 and GPR8 map to chromosomes 10q11.2-q21.1 and 10q13.3, respectively.
Function:
GPR7 interacts specifically with a number of opioid ligands. It is a receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals, and has a higher affinity for neuropeptide B. It has been reported in brain, mainly cerebellum and frontal cortex, and in the pituitary (O'Dowd et al., 1995). The mouse ortholog of GPR7 was shown by in situ hybridization to be expressed in discrete nuclei of brain, namely suprachiasmatic, arcuate, and ventromedial nuclei of hypothalamus.
Subcellular Location:
Cell membrane; Multipass membrane protein.
SWISS:
O95800
Gene ID:
10936
Database links:
Entrez Gene: 428544 Chicken
Entrez Gene: 539470 Cow
Entrez Gene: 101130191 Gorilla
Entrez Gene: 100066961 Horse
Entrez Gene: 10936 Human
Entrez Gene: 237716 Mouse
Entrez Gene: 100517153 Pig
Entrez Gene: 100347723 Rabbit
Entrez Gene: 498434 Rat
Omim: 606704 Human
SwissProt: O95800 Human
SwissProt: Q6X632 Mouse
Unigene: 40763 Human
Unigene: 338361 Mouse
Unigene: 484157 Mouse
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Sample:
Heart (Mouse) Lysate at 40 ug
Primary: Anti-GPR7 (SL8618R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 59 kD
Observed band size: 59 kD
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