Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger and BTB domain-containing protein 5 (ZBTB5) is a 677 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZBTB5 contains a BTB domain, also known as a POZ domain, which inhibits DNA binding and mediates homotypic and heterotypic dimerization. Characteristics of the BTB domain suggest that ZBTB5 functions as a transcription regulator.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed with highest levels in brain.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers.
SWISS:
Q15916
Gene ID:
10773
Database links:
Entrez Gene: 10773 Human
Entrez Gene: 241322 Mouse
Entrez Gene: 366029 Rat
Omim: 605976 Human
SwissProt: Q15916 Human
SwissProt: Q8K088 Mouse
Unigene: 654596 Human
Unigene: 330182 Mouse
Unigene: 39069 Rat
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Sample:
HepG2 Cell (Human) Lysate at 30 ug
Primary: Anti- ZBTB6 (SL13582R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 48 kD
Observed band size: 48 kD
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