IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 14788) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).
Function:
Potential ligand of the IGFLR1 cell membrane receptor.
Subcellular Location:
Secreted (Potential).
Tissue Specificity:
Detected in cerebellum, heart, placenta, spleen, stomach, testis and thymus.
Similarity:
Belongs to the IGFL family.
SWISS:
Q6UWQ7
Gene ID:
147920
Database links:
Entrez Gene: 147920 Human
SwissProt: Q6UWQ7 Human
Unigene: 99376 Human
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Paraformaldehyde-fixed, paraffin embedded (Human stomach cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IGF like family member 2; IGFL2) Polyclonal Antibody, Unconjugated (SL15571R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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