Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004].
Function:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.
Tissue Specificity:
Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung.
Similarity:
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
SWISS:
Q86UL3
Gene ID:
137964
Database links:
Entrez Gene: 137964 Human
Entrez Gene: 102247 Mouse
Entrez Gene: 290843 Rat
SwissProt: A3FPG8 Cow
SwissProt: Q86UL3 Human
SwissProt: Q8K2C8 Mouse
SwissProt: Q0ZFS7 Rat
Unigene: 355753 Human
Unigene: 200898 Mouse
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Sample:
Uterus (Mouse) Lysate at 40 ug
Primary: Anti- GPAT4 (SL15587R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 48 kD
Observed band size: 48 kD
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