AN11;
Dcaf7;
DCAF7_HUMAN;
DDB1- and CUL4-associated factor 7;
HAN11;
Human anthocyanin;
Petunia;
Seven WD repeat protein of the AN11 family 1;
SWAN 1;
WD repeat domain 68;
WD repeat protein An11 homolog;
WD repeat-containing protein 68;
WD rep
Cat:
SL13682R
Species Reactivity：
(predicted: Human,Mouse,Rat,Horse,)
Immunogen：
KLH conjugated synthetic peptide derived from human WDR68:2-100/342
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: Spleen (Mouse) Lysate at 40 ugPrimary: Anti-WDR68 (SL13682R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 39 kDObserved band size: 39 kD
Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Function: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
Subunit: Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1. Interacts with ZNF703.
Subcellular Location: Cytoplasm. Nucleus. Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
Post-translational modifications: Protein modification; protein ubiquitination.
Similarity: Belongs to the WD repeat DCAF7 family.
Contains 4 WD repeats.
