AI604396;
Copper transporter 2;
COPT2;
COPT2_HUMAN;
CTR2;
hCTR2;
MGC117640;
Probable low affinity copper uptake protein 2;
RP23 64F17.2;
SLC31A2;
Solute carrier family 31 member 2;
Solute carrier family 31, member 2.
Cat:
SL13981R
Species Reactivity:
Human,(predicted: Mouse,Rat,Rabbit,)
Immunogen:
KLH conjugated synthetic peptide derived from human COPT2:1-100/143
Format:
Liquid
Storage instructions:
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration:
1mg/ml
Clonality:
Polyclonal
Isotype:
IgG
Applications:
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500(Paraffin sections need to do antigen repair)not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host:
Rabbit
Product Overview:
Sample: Siha(Human) Cell Lysate at 30 ugPrimary: Anti- COPT2 (SL13981R) at 1/1000 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 16 kDObserved band size: 18 kD
The activity of a diverse subset of enzymes relies on the essential nutrient copper to perform important processes including signaling to the transcription and protein trafficking machinery, oxidative phosphorylation, iron mobilization, neuropeptide maturation, and normal development. Copper uptake requires tight regulation to ensure that sufficient copper is present in the cell to drive vital cellular processes, while avoiding the accumulation of copper to toxic levels. The copper transporter 2 (COPT2), also designated CTR2 or Solute carrier family 31 member 2 (SLC31A2), is a 143 amino acid protein mediates the uptake of copper in mammalian cells. COPT2 has been shown to localize to the plasma membrane, endosomes and lysosomes, where it plays a role in maintaining copper homeostasis. COPT2 also mediates the uptake of the chemotherapeutic drugs cisplatin and carboplatin and may modulate the sensitivity and toxicity of these drugs.
Function: Involved in low-affinity copper uptake.
Subcellular Location: Membrane.
Tissue Specificity: Ubiquitous.
Similarity: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.