CR16 is a 483 amino acid proline-rich cytoplasmic protein that is thought to regulate cytoskeletal organization. A member of both the verprolin and Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) families, CR16 colocalizes with N-WASP (Neuronal Wiskott-Aldrich syndrome protein) in tips of growth cone filopodia, primary hippocampal neurons and Sertoli cell-spermatid junctions. CR16 and N-WASP functionally interact to influence spermatogenesis. CR16 is predominantly expressed in brain and testis, contains one WH2 domain, a KLKR motif, three profilin-binding motifs and is encoded by a gene that maps to human chromosome 7p15.1.
Function:
May be a regulator of cytoskeletal organization. May have a role in spermatogenesis.
Subcellular Location:
Cytoplasm. In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone.
Similarity:
Belongs to the verprolin family.
Contains 1 WH2 domain.
SWISS:
A6NGB9
Gene ID:
644150
Database links:
Entrez Gene: 644150 Human
SwissProt: A6NGB9 Human
Unigene: 709280 Human
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Sample:
Large intestine (Mouse) Lysate at 40 ug
Primary: Anti- CR16 (SL14041R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49kD
Observed band size: 49 kD
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