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Home > Product > Antibody > Rabbit Anti-CRLF3 antibody
CREME 9; CREME9; CRLF 3; CRLM9; Cytokine receptor like factor 3; Cytokine receptor like molecule 9; Cytokine receptor related protein 4; CYTOR4; FRWS; MGC20661; P48; p48.2; Type I cytokine receptor like factor; Type I cytokine receptor like factor p48; CR
Cat:
SL14062R
Species Reactivity：
Mouse,(predicted: Human,Rat,Dog,Cow,Rabbit,)
Immunogen：
KLH conjugated synthetic peptide derived from human CRLF3:21-120/442
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CRLF3) Polyclonal Antibody, Unconjugated (SL14062R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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Product PDFs
Datasheet:


This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]

Function:
CRLF3 (Cytokine receptor-like factor 3) contains one fibronectin type-III domain. It is expressed in skin and squamous cell carcinoma (SCC) and in lesion actinic keratosis (AK).

Subcellular Location:
Cytoplasmic

Tissue Specificity:
Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).

Similarity:
Belongs to the cytokine receptor-like factor 3 family.
Contains 1 fibronectin type-III domain.

SWISS:
Q8IUI8

Gene ID:
51379

Database links:

Entrez Gene: 51379 Human

Entrez Gene: 54394 Mouse

Omim: 614853 Human

SwissProt: Q8IUI8 Human

SwissProt: Q9Z2L7 Mouse

Unigene: 649372 Human

Unigene: 272093 Mouse



Picture

Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CRLF3) Polyclonal Antibody, Unconjugated (SL14062R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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