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Home > Product > Antibody > Rabbit Anti-COPT2 antibody
AI604396; Copper transporter 2; COPT2; COPT2_HUMAN; CTR2; hCTR2; MGC117640; Probable low affinity copper uptake protein 2; RP23 64F17.2; SLC31A2; Solute carrier family 31 member 2; Solute carrier family 31, member 2.
Cat:
SL10622R
Species Reactivity：
Rat,(predicted: Human,Mouse,)
Immunogen：
KLH conjugated synthetic peptide derived from human COPT2
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (COPT2) Polyclonal Antibody, Unconjugated (SL10622R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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Product PDFs
Datasheet:


The activity of a diverse subset of enzymes relies on the essential nutrient copper to perform important processes including signaling to the transcription and protein trafficking machinery, oxidative phosphorylation, iron mobilization, neuropeptide maturation, and normal development. Copper uptake requires tight regulation to ensure that sufficient copper is present in the cell to drive vital cellular processes, while avoiding the accumulation of copper to toxic levels. The copper transporter 2 (COPT2), also designated CTR2 or Solute carrier family 31 member 2 (SLC31A2), is a 143 amino acid protein mediates the uptake of copper in mammalian cells. COPT2 has been shown to localize to the plasma membrane, endosomes and lysosomes, where it plays a role in maintaining copper homeostasis. COPT2 also mediates the uptake of the chemotherapeutic drugs cisplatin and carboplatin and may modulate the sensitivity and toxicity of these drugs.

Function:
Involved in low-affinity copper uptake (Potential).

Subcellular Location:
Membrane; Multi-pass membrane protein (Probable).

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain.

Similarity:
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.

SWISS:
O15432

Gene ID:
1318

Database links:

Entrez Gene: 1318 Human

Entrez Gene: 20530 Mouse

Omim: 603088 Human

SwissProt: O15432 Human

SwissProt: Q9CPU9 Mouse

Unigene: 4830 Human

Unigene: 292539 Mouse



Picture

Paraformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (COPT2) Polyclonal Antibody, Unconjugated (SL10622R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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