This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Function:
High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Subunit:
Heterodimer with NRP1. Binds PLXNB1.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.
SWISS:
O60462
Gene ID:
8828
Database links:
Entrez Gene: 8828 Human
Entrez Gene: 18187 Mouse
Entrez Gene: 81527 Rat
Entrez Gene: 374157 Chicken
Entrez Gene: 541004 Cow
Omim: 602070 Human
SwissProt: O60462 Human
SwissProt: O35375 Mouse
SwissProt: O35276 Rat
Unigene: 47240 Human
Unigene: 266341 Mouse
Unigene: 10816 Rat
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Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,SLC0005) at 37℃ for 20 min;
Incubation: Anti-Neuropilin 2/NRP2 Polyclonal Antibody, Unconjugated(SL10241R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(SLC0010) staining
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