EF hand domain containing protein 2;
EF hand domain family, member D2;
EF-hand domain-containing protein D2;
EFHD 2;
EFHD2;
EFHD2_HUMAN;
RP3-467K16.3;
Swiprosin 1;
Swiprosin-1;
SWS1.
Cat:
SL14520R
Species Reactivity：
Mouse,(predicted: Human,Rat,Pig,Cow,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human EFHD2:51-150/240
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Protein:spleen(mouse) lysate at 40ug; Primary: rabbit Anti-EFHD2 (SL14520R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000; Predicted band size: 27 kDObserved band size: 27 kD
EFHD2 is a 48 amino acid protein that regulates spontaneous apoptosis through the regulation of Bcl-xS abundance. Localized to membrane raft, Swiprosin-1 is expressed in lymphocytes and contains two EF-hand domains. The gene encoding Swiprosin-1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Function: May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
Subcellular Location: Membrane raft. In immature B-cell line WEHI231.
Tissue Specificity: Found in lymphocytes; preferentially expressed in CD8+ cells.
