This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
Subunit:
Interacts with METTL18.
Subcellular Location:
Nucleus, nucleolus.
Similarity:
Contains 5 WD repeats.
SWISS:
Q9BQ67
Gene ID:
83743
Database links:
Entrez Gene: 468939 Chimpanzee
Entrez Gene: 540739 Cow
Entrez Gene: 83743 Human
Entrez Gene: 612058 Dog
Entrez Gene: 101144842 Gorilla
Entrez Gene: 100733019 Guinea pig
Entrez Gene: 100051020 Horse
Entrez Gene: 100386385 Marmoset (common)
Entrez Gene: 100441405 Orangutan
Entrez Gene: 717966 Rhesus monkey
Omim: 610597 Human
SwissProt: Q1JQD2 Cow
SwissProt: Q9BQ67 Human
Unigene: 400625 Human
Picture |
Paraformaldehyde-fixed, paraffin embedded (Rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GRWD1) Polyclonal Antibody, Unconjugated (SL16328R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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