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Home > Product > Antibody > Rabbit Anti-TRIM5 gamma antibody
RING finger protein 88; RNF88; TRIM5; TRIM5_HUMAN; TRIM5alpha; Tripartite motif containing 5; Tripartite motif protein 5; Tripartite motif protein TRIM5; Tripartite motif-containing protein 5; Weakly similar to regulatory protein rpt 1 [M.musculu
Cat:
SL16745R
Species Reactivity：
Rat,(predicted: Human,)
Immunogen：
KLH conjugated synthetic peptide derived from human TRIM5 gamma:301-360/493
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Paraformaldehyde-fixed, paraffin embedded (rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TRIM5) Polyclonal Antibody, Unconjugated (SL16745R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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Unit:
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Product PDFs
Datasheet:


Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HISLV1. May have E3 ubiquitin-protein ligase activity.

Subcellular Location:
Cytoplasm > P-body. Cytoplasmic bodies.

Post-translational modifications:
Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).

Similarity:
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger.

SWISS:
Q9C035

Gene ID:
85363

Database links:

Entrez Gene: 85363 Human

Omim: 608487 Human

SwissProt: Q9C035 Human

Unigene: 370515 Human



Picture

Paraformaldehyde-fixed, paraffin embedded (rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TRIM5) Polyclonal Antibody, Unconjugated (SL16745R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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