LRRC17 is a 441 amino acid protein that localizes to the cytoplasm and contains six LRR repeats. The protein is expressed at high levels in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung. LRRC17 is expressed at higher levels in non-neuronal (S-type) neuroblastoma cells than in neuroblastic (N-type) neuroblastoma cells.
Function:
Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors.
Subcellular Location:
Secreted; extracellular space.
Tissue Specificity:
Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells.
Similarity:
Contains 6 LRR (leucine-rich) repeats.
Contains 2 LRRCT domains.
Contains 1 LRRNT domain.
SWISS:
Q8N6Y2
Gene ID:
10234
Database links:
Entrez Gene: 10234 Human
Entrez Gene: 777690 Cow
Entrez Gene: 100050177 Horse
Entrez Gene: 74511 Mouse
Entrez Gene: 100737774 Pig
Entrez Gene: 100340395 Rabbit
Entrez Gene: 502715 Rat
SwissProt: Q8N6Y2 Human
SwissProt: Q9CXD9 Mouse
Unigene: 567412 Human
Unigene: 439963 Mouse
Unigene: 207235 Rat
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Sample:
Spleen (Mouse) Lysate at 40 ug
Lung (Mouse) Lysate at 40 ug
Primary: Anti- LRRC17 (SL18368R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kD
Observed band size: 50 kD
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