KLH conjugated synthetic peptide derived from human ZDHHC2/ZNF372:201-300/367
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Sample: Cerebrum (Mouse) Lysate at 40 ugCerebellum (Mouse) Lysate at 40 ugPrimary: Anti- ZDHHC2/ZNF372 (SL1896R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 42 kDObserved band size: 45 kD
ZDHHC2 is a 367 amino acid multi-pass membrane protein that contains one DHHSLCtype zinc finger. The ubiquitously expressed ZDHHC2 protein functions as a palmitoyltransferase that uses palmitoyl-CoA and catalyzes the conversion of target proteins, namely GAP-43 and PSD-95, to S-palmitoyl proteins. Defects in the gene encoding ZDHHC2 are found in colorectal cancer and hepatocellular carcinoma, suggesting a role for ZDHHC2 in tumorigenesis. The gene encoding human ZDHHC2 maps to chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.
Function: Palmitoyltransferase specific for GAP43 and DLG4/PSD95.
Subcellular Location: Membrane.
Tissue Specificity: Ubiquitously expressed. Reduced expression in colorectal cancers with liver metastasis.
DISEASE: Note=Mutations in ZDHHC2 are found in hepatocellular carcinoma and colorectal cancer.
Similarity: Belongs to the DHHC palmitoyltransferase family.
Contains 1 DHHSLCtype zinc finger.
Sample:
Cerebrum (Mouse) Lysate at 40 ug
Cerebellum (Mouse) Lysate at 40 ug
Primary: Anti- ZDHHC2/ZNF372 (SL1896R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 42 kD
Observed band size: 45 kD
