MEGF11 is a 1,044 amino acid single-pass type I membrane protein that belongs to the MEGF family. MEGF11 exists as a homopolymer that primarily localizes to protruding lamellipodia in an irregular, mosaic-like adhesion pattern. Expressed at high levels in adult and fetal brain and adult spinal cord, MEGF11 is found at lower levels in kidney, ovary and heart. MEGF11 contains fourteen EGF-like domains, one EMI domain, and undergoes alternative splicing events to produce four isoforms. The gene encoding MEGF11 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
Function:
May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note: Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10.
Similarity:
Belongs to the MEGF family.
Contains 14 EGF-like domains.
Contains 1 EMI domain.
SWISS:
A6BM72
Gene ID:
84465
Database links:
Entrez Gene: 84465 Human
Entrez Gene: 214058 Mouse
Entrez Gene: 691517 Rat
Entrez Gene: 563468 Zebrafish
Omim: 612454 Human
SwissProt: A6BM72 Human
SwissProt: Q80T91 Mouse
Unigene: 712886 Human
Unigene: 127721 Mouse
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Sample:
Cerebellum (Mouse) Lysate at 40 ug
Primary: Anti-MEGF11 (SL18775R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 110 kD
Observed band size: 110 kD
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