Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the ribosomal protein S8e family.
SWISS:
P62241
Gene ID:
6202
Database links:
Entrez Gene: 6202 Human
Entrez Gene: 100040298 Mouse
Entrez Gene: 20116 Mouse
Entrez Gene: 65136 Rat
Omim: 600357 Human
SwissProt: P62241 Human
SwissProt: P62242 Mouse
SwissProt: P62243 Rat
Unigene: 512675 Human
Unigene: 338718 Mouse
Unigene: 485034 Mouse
Unigene: 3198 Rat
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Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RPS8) Polyclonal Antibody, Unconjugated (SL18834R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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