The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a SLCterminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008]
Function:
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions
Subunit:
Component of the SCMC which also includes at least OOEP and TLE6
Subcellular Location:
Mitochondrion. Nucleus > nucleolus. Cytoplasm. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions.
Tissue Specificity:
Oocyte-specific.
Similarity:
Belongs to the NLRP family.
Contains 1 DAPIN domain.
Contains 13 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
SWISS:
P59047
Gene ID:
126206
Database links:
Entrez Gene: 126206 Human
Entrez Gene: 23968 Mouse
Entrez Gene: 308325 Rat
Omim: 609658 Human
SwissProt: P59047 Human
SwissProt: Q9R1M5 Mouse
Unigene: 356872 Human
Unigene: 333653 Mouse
| Picture |
Paraformaldehyde-fixed, paraffin embedded (rat ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NALP5) Polyclonal Antibody, Unconjugated (SL19006R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
|
|
|
