This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Function:
Involved in the control of cell growth and differentiation.
Subunit:
Homotrimer. Binds to PKC beta-1. Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization.
Subcellular Location:
Secreted.
Similarity:
Contains 6 EGF-like domains.
Contains 1 TSP N-terminal (TSPN) domain.
Contains 5 VWFC domains.
SWISS:
Q92832
Gene ID:
4745
Database links:
Entrez Gene: 4745 Human
Entrez Gene: 338352 Mouse
Entrez Gene: 81733 Rat
Omim: 602319 Human
SwissProt: Q92832 Human
SwissProt: Q2VWQ2 Mouse
SwissProt: Q62919 Rat
Unigene: 657172 Human
Unigene: 383528 Mouse
Unigene: 10695 Rat
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Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NELL1) Polyclonal Antibody, Unconjugated (SL10704R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NELL1) Polyclonal Antibody, Unconjugated (SL10704R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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