FLJ10267;
MGC986;
NOL1;
NOL1-related protein;
NOL1/NOP2/Sun domain family member 5;
NOL1R;
NOP2/Sun domain family, member 5;
NOP2/Sun domain family, member 5A;
NSUN5;
NSUN5_HUMAN;
p120;
Putative methyltransferase NSUN5;
WBSCR20;
WBSCR20A;
Wi
Cat:
SL1996R
Species Reactivity：
Human,
Immunogen：
KLH conjugated synthetic peptide derived from human NSUN5:2-100/429
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Product Overview：
Protein: U251(human)cell lyates at 40ug;Primary: Rabbit Anti-NSUN5 (SL1996R) at 1:300; Secondary: 800CW Conjugated Goat (polyclonal) Anti-Rabbit IgG(H+L) at 1: 10000; Predicted band size:47 kDObserved band size:47 kD
This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Function: May have S-adenosyl-L-methionine-dependent methyl-transferase activity.
Tissue Specificity: Ubiquitous. Detected in placenta, heart and skeletal muscle.
Post-translational modifications: Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE: Note=NSUN5 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.
Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family.
