This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]
Function:
Synthesizes selenophosphate from selenide and ATP.
Subunit:
Homodimer (isoform 1, isoform 2, isoform 3 and isoform 4). Heterodimer of isoform 1 and isoform 3. Heterodimer of isoform 2 and isoform 4.
Tissue Specificity:
Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and then decreased. Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased.
Similarity:
Belongs to the selenophosphate synthase 1 family. Class II subfamily.
SWISS:
P49903
Gene ID:
22929
Database links:
Entrez Gene: 22929 Human
Entrez Gene: 426612 Chicken
Entrez Gene: 507470 Cow
Entrez Gene: 477999 Dog
Entrez Gene: 109079 Mouse
Entrez Gene: 291314 Rat
Entrez Gene: 379650 Xenopus laevis
Entrez Gene: 448749 Xenopus tropicalis
Entrez Gene: 324947 Zebrafish
Omim: 600902 Human
SwissProt: Q0VC82 Cow
SwissProt: P49903 Human
SwissProt: Q8SH69 Mouse
SwissProt: Q6PF47 Xenopus laevis
SwissProt: Q6GL12 Xenopus tropicalis
SwissProt: Q7ZW38 Zebrafish
Unigene: 14827 Human
Unigene: 34329 Mouse
Unigene: 100803 Rat
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Protein: bone(mouse) lysate at 40ug;
Primary: rabbit Anti-SEPHS1(SL19627R) at 1:300;
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 43 kD
Observed band size: 36 kD
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