OLFML2A contains one olfactomedin-like domain. Its exact function is unknown. There are three named isoforms produced by alternative splicing.
Subunit:
Homodimer. Binds to heparin and chondroitin sulfate E.
Subcellular Location:
Secreted
Tissue Specificity:
In the kidney expressed only by podocytes, wherein they localize to major processes.
DISEASE:
Detected at the vesicle stage of developing glomeruli, expressed in invading endothelial cells in the glomerular cleft at the S-shaped stage and is later expressed only at the basal aspect of maturing podocytes.
SWISS:
Q68BL7
Gene ID:
169611
Database links:
Entrez Gene: 169611 Human
Entrez Gene: 241327 Mouse
Entrez Gene: 296708 Rat
SwissProt: Q68BL7 Human
SwissProt: Q8SHP7 Mouse
Unigene: 357004 Human
Unigene: 103491 Mouse
Unigene: 144357 Rat
| Picture |
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (OLFML2A) Polyclonal Antibody, Unconjugated (SL19639R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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