This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Subcellular Location:
Nucleus membrane. Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane.
Tissue Specificity:
Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues.
Similarity:
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
SWISS:
Q93084
Gene ID:
489
Database links:
Entrez Gene: 395707 Chicken
Entrez Gene: 512313 Cow
Entrez Gene: 489 Human
Entrez Gene: 53313 Mouse
Entrez Gene: 25391 Rat
Entrez Gene: 49588 Xenopus laevis
Entrez Gene: 779786 Xenopus tropicalis
Omim: 601929 Human
SwissProt: Q9YGL9 Chicken
SwissProt: Q93084 Human
SwissProt: Q64518 Mouse
SwissProt: P18596 Rat
Unigene: 513870 Human
Unigene: 6306 Mouse
Unigene: 9920 Rat
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Sample:
Jurkat Cell (Human) Lysate at 40 ug
RajiCell (Human) Lysate at 40 ug
K562 Cell (Human) Lysate at 40 ug
Primary: Anti-SERCA3(SL19653R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 114kD
Observed band size: 114kD
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