The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
Function:
Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.
Subunit:
Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).
Subcellular Location:
Cell membrane. Cell junction > gap junction. Endoplasmic reticulum membrane.
Similarity:
Belongs to the pannexin family.
SWISS:
Q96RD7
Gene ID:
24145
Database links:
Entrez Gene: 24145 Human
Entrez Gene: 55991 Mouse
Entrez Gene: 100171730 Orangutan
Entrez Gene: 315435 Rat
Omim: 608420 Human
SwissProt: Q96RD7 Human
SwissProt: Q9JIP4 Mouse
SwissProt: Q5REE3 Orangutan
SwissProt: P60570 Rat
Unigene: 591976 Human
Unigene: 142253 Mouse
Unigene: 204521 Rat
| Picture |
Sample:Muscle (Mouse)Lysate at 40 ug
Primary: Anti-Pannexin 1(SL21015R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 48kD
Observed band size: 53kD
|
|
|
