This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, May 2010]
Function:
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
Subunit:
Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (Probable).
Subcellular Location:
Nuclear
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the PDS5 family.
Contains 3 A.T hook DNA-binding domains.
Contains 1 HEAT repeat.
SWISS:
Q9NTI5
Gene ID:
23047
Database links:
Entrez Gene: 23047 Human
Entrez Gene: 100710 Mouse
Entrez Gene: 304218 Rat
Omim: 605333 Human
SwissProt: Q9NTI5 Human
SwissProt: Q4VA53 Mouse
SwissProt: Q6TRW4 Rat
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Sample:
Brain (Mouse) Lysate at 40 ug
Primary: Anti-PDS5B (SL12605R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 165 kD
Observed band size: 165 kD
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