The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Function:
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage.
Subcellular Location:
Nucleus speckle. Nucleus. In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.
Post-translational modifications:
Phosphorylated on tyrosine residues.
Similarity:
Contains 1 WW domain.
SWISS:
Q9BTA9
Gene ID:
51322
Database links:
Entrez Gene: 51322 Human
Entrez Gene: 225131 Mouse
Omim: 615049 Human
SwissProt: Q9BTA9 Human
SwissProt: Q924H7 Mouse
Unigene: 435610 Human
Unigene: 204524 Mouse
Unigene: 482081 Mouse
Unigene: 491095 Mouse
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Sample:
Spleen (Mouse) Lysate at 40 ug
Primary: Anti-WAC (SL12787R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 71 kD
Observed band size: 71 kD
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